We filed more than 30 patents from the work originated in the BMRC, some of which led to several spin-offs. Verinata Health (formerly Living MicroSystems and then Artemis Health) focused on prenatal diagnosis has raised over $70 million in three rounds of VC funding, and was recently been acquired by Illumina, Inc. for $450 million.
Daktari, Inc started by one of our collaborators, Dr. William Rodriguez, has licensed the CD4 chip to enter into product development and is currently proceeding with testing the chip in Africa. Several other companies significantly benefited from collaborations with BMRC.
Firefly BioWorks, uses the technology originally described in Science (2007) with our collaborator, Patrick Doyle at MIT, towards customizable microRNA detection platforms.
Hurel develops organ-on-a chip devices for industrial and academic research uses, and has recently obtained Series A venture funding for development of technology that was codeveloped by Dr. Yarmush at the BMRC.
The technology transfer activities are managed through the Partners Healthcare Research Ventures and Licensing (RVL) office at the MGH.
|Photoactivated Release of Cells from Surfaces
|Formation of High-Density Cell Arrays in Antibody-Modified Poly(ethylene glycol) Microwells and Sorting of Cells from the Array
|Microfabricated Bioreactor for the High Titer Production and Storage of Retroviral Vectors
|Bioactive Nanopatterned Surfaces for Cell-Ligand Interaction Studies and Cell Capture
|Microfluidic Device and Protocol for Isolating High Quality Total RNA from Small Samples (Less than 1000 Cells)
|A High-Density Microfludic Array of Primary Cells in Co-Culture for Use in High Throughput Physiology Studies
|A Microfluidic Chip for CD+4 T Cell Count Based on Flow Assisted Cell Affinity Isolation
|Cell Lysis Impedance Spectroscopy for Microscale Cellular Diagnostics, Including CD4 Counting
|Inertial Focusing and Separation of Particles
|Microfluidic Devices for Polar Stimulation of Migratory Cells in 3-D Like Environment
|Monitoring Response to Anti-Cancer Therapy Using Circulating Tumor Cells
|Detection of Circulating Tumor Cells in the Peripheral Blood of Prostate Cancer Patients with Clinically Localized Disease
|On Chip Cell Lysate Fractionation Methodology to Extract DNA/RNA from CTCs for Molecular Analysis
|Microfluidic Platform for Monitoring of Granulocyte Levels in a Clinical Setting
|Continuous-Flow Cell and Particle Position and Velocity Control
|Chemotaxis Assay of Neutrophils Isolated Directly from Whole Blood in a Microfluidic Device
|Continuous Particle Separation by Differential Lateral Placement of Particles by Hydrodynamic Focusing
|Controlled Encapsulation of Single Cells into Monodisperse Picoliter Drops
|Electromagnetic Enumeration of Magnetically Labeled Cells and Particles
|Oxygenated Cocultures for High Levels of Liver Specific Function
|Herringbone Microfluidic Device for Isolating Rare Cells from Blood
|Microfabricated Slide for Quantitating Cell Migration in a Wound Healing Assays
|Colloidal Hydrogel Particles with Tunable Chemistry, Geometry, and Flexibility
|Particle Sizing by Inertial Ordering Equilibrium Position
|Functional, Reversible Microscale Films
|Quantitative Cell Motility Assay
|Microfluidic Isolation and Analysis of Microvesicles
|Method to Produce Low-Impedance Nanoporous Gold Electrodes for Electrophysiological Applications
|A Microscale Particle Counting System Using Subtraction Impedance Cytometry
|Carbon Nanotube Forests Encapsulated Inside Microfluidic Channels For Bioparticle Separation
|Concentration Of Bacteria From Biological Fluids